Wednesday, July 28, 2010

Lipitor

Referring to the ‘Blue Book MOH’, statin available in Malaysia :

Atorvastatin 20 mg Tablet
Atorvastatin 40 mg Tablet
Atorvastatin 80 mg Tablet
Ezetimibe 10 mg & Simvastatin 20 mg Tablet
Lovastatin 20 mg Tablet
Lovastatin 20 mg Tablet
Rosuvastatin 10 mg Tablet
Rosuvastatin 20 mg Tablet
Simvastatin 10 mg Tablet
Simvastatin 20 mg Tablet
Simvastatin 40 mg Tablet


This group of drug is used to lower LDL-cholestrol

Brand name of atorvastatin = Lipitor. Atorvastatin was first synthesized in 1985 by Bruce Roth while working at Parke-Davis Warner-Lambert Company (now Pfizer). With 2008 sales of US$12.4 billion, Lipitor was the top-selling branded pharmaceutical in the world. US patent protection is scheduled to expire in June 2011. http://www.lipitor.com/

LIPITOR is an inhibitor of HMG-CoA reductase (statin) indicated as an adjunct therapy to diet to:
• Reduce the risk of MI, stroke, revascularization procedures, and angina in patients without CHD, but with multiple risk factors (1.1).
• Reduce the risk of MI and stroke in patients with type 2 diabetes without CHD, but with multiple risk factors (1.1).
• Reduce the risk of non-fatal MI, fatal and non-fatal stroke, revascularization procedures, hospitalization for CHF, and angina in patients with CHD (1.1).
• Reduce elevated total-C, LDL-C, apo B, and TG levels and increase HDL-C in adult patients with primary hyperlipidemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (1.2).
• Reduce elevated TG in patients with hypertriglyceridemia and primary dysbetalipoproteinemia (1.2).
• Reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH) (1.2).
• Reduce elevated total-C, LDL-C, and apo B levels in boys and postmenarchal girls, 10 to 17 years of age, with heterozygous familial hypercholesterolemia after failing an adequate trial of diet therapy (1.2).

Read the prescribing leaflet - http://www.pfizer.com/files/products/uspi_lipitor.pdf

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